The Origin of the Lepra Cell

Type 2 lepra reaction as a cause of pyrexia of unknown origin.

Leprosy, a commonly encountered disease, can rarely present as a reactional state de novo with fever as the main presenting feature. Here we describe an uncommon presentation of leprosy [with type 2 lepra reaction] as pyrexia of unknown origin with prominent rheumatologic manifestations [acute polyarthritis], renal involvement and generalized lymphadenopathy with rare presentation of type 2 lep...

I-30: The Mesenchymal Stem Cell - The Origin of Endometriosis

The Origin of the Lepra

One of the most striking features of the anatomical changes which develop in leprosy is the occurrence in the lesion of great numbers of large phagocytic cells filled with bacilli. These cells were first noted by Virchow, I and were given the name of "lepta cells" by him. Later investigation has shown that they are characteristic of the disease, the leprous nodule being composed almost entirely...

Case of Lepra Arabum, or True Elephantiasis

Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells.

BACKGROUND INFORMATION Leptin, an adipocyte-secreted hormone, signals through activation of its membrane-embedded receptor (LEPR). To study the leptin-induced events occurring in short (LEPRa) and long (LEPRb) LEPRs in the cell membrane, by FRET (fluorescence resonance energy transfer) methodology, the respective receptors, tagged at their C-terminal with CFP (cyan fluorescent protein) or YFP (...